产品名称
PRDX3 Rabbit Polyclonal Antibody (C-term)
别名
Thioredoxin-dependent peroxide reductase, mitochondrial, Antioxidant protein 1, AOP-1, HBC189, Peroxiredoxin III, Prx-III, Peroxiredoxin-3, Protein MER5 homolog, PRDX3, AOP1
存储缓冲液
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) New type preservative N. This antibody is purified through a protein A column, followed by peptide affinity purification.
Human Swissprot No.
P30048
特异性
This PRDX3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 229-262 amino acids from the C-terminal region of human PRDX3.
运输及保存条件
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
背景介绍
Involved in redox regulation of the cell. Protects radical-sensitive enzymes from oxidative damage by a radical- generating system. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol.
细胞定位
Mitochondrion {ECO:0000250|UniProtKB:P35705}. Cytoplasm. Early endosome. Note=Localizes to early endosomes in a RPS6KC1-dependent manner.
功能
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides (PubMed:
7733872, PubMed:
17707404). Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol (PubMed:
12492477).
