产品名称
CCG8 Rabbit Polyclonal Antibody
蛋白名称
Voltage-dependent calcium channel gamma-8 subunit (Neuronal voltage-gated calcium channel gamma-8 subunit) (Transmembrane AMPAR regulatory protein gamma-8) (TARP gamma-8)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q8WXS5
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8WXS5/entry
Mouse Swissprot No.
Q8VHW2
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8VHW2
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q8VHW5
免疫原
Synthesized peptide derived from human protein . at AA range: 140-220
特异性
CCG8 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
calcium voltage-gated channel auxiliary subunit gamma 8(CACNG8) Homo sapiens The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type II TARP and a calcium channel gamma subunit. The mRNA for this gene is believed to initiate translation from a non-AUG (CUG) start codon. [provided by RefSeq, Dec 2010],
组织表达
Detected in heart left ventricle.
细胞定位
Cell membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic density membrane .
信号通路
MAPK_ERK_Growth;MAPK_G_Protein;Cardiac muscle contraction;Hypertrophic cardiomyopathy (HCM);Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;
功能
function:Thought to stabilize the calcium channel in an inactivated (closed) state.,similarity:Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.,subunit:The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
