产品名称
VDAC3 Rabbit Polyclonal Antibody
蛋白名称
Voltage-dependent anion-selective channel protein 3 (VDAC-3) (hVDAC3) (Outer mitochondrial membrane protein porin 3)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9Y277
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Y277/entry
Mouse Swissprot No.
Q60931
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q60931
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q9R1Z0
免疫原
Synthesized peptide derived from part region of human protein
特异性
VDAC3 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a voltage-dependent anion channel (VDAC), and belongs to the mitochondrial porin family. VDACs are small, integral membrane proteins that traverse the outer mitochondrial membrane and conduct ATP and other small metabolites. They are known to bind several kinases of intermediary metabolism, thought to be involved in translocation of adenine nucleotides, and are hypothesized to form part of the mitochondrial permeability transition pore, which results in the release of cytochrome c at the onset of apoptotic cell death. Alternatively transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011],
组织表达
Expressed in erythrocytes (at protein level) (PubMed:27641616). Widely expressed. Highest in testis (PubMed:9781040).
细胞定位
Mitochondrion outer membrane . Membrane . May localize to non-mitochondrial membranes. .
信号通路
Calcium;Parkinson's disease;Huntington's disease;
功能
domain:Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands.,function:Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.,similarity:Belongs to the eukaryotic mitochondrial porin family.,tissue specificity:Widely expressed. Highest in testis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
