产品名称
MME Rabbit Polyclonal Antibody (N-term)
别名
Neprilysin, Atriopeptidase, Common acute lymphocytic leukemia antigen, CALLA, Enkephalinase, Neutral endopeptidase 2411, NEP, Neutral endopeptidase, Skin fibroblast elastase, SFE, CD10, MME, EPN
存储缓冲液
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) New type preservative N. This antibody is purified through a protein A column, followed by peptide affinity purification.
Human Swissprot No.
P08473
特异性
This MME antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 99-132 amino acids from the N-terminal region of human MME.
运输及保存条件
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
背景介绍
Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV- inducible elastase activity toward skin preelastic and elastic fibers.
细胞定位
Cell membrane; Single-pass type II membrane protein
功能
Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:
15283675, PubMed:
8168535). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:
17101991). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:
15283675). Involved in the degradation of atrial natriuretic factor (ANF) and brain natriuretic factor (BNP(1- 32)) (PubMed:
2531377, PubMed:
2972276, PubMed:
16254193). Displays UV- inducible elastase activity toward skin preelastic and elastic fibers (PubMed:
20876573).
