产品名称
SEC20 Rabbit Polyclonal Antibody
基因名称
BNIP1 NIP1 SEC20L TRG8
蛋白名称
Vesicle transport protein SEC20 (BCL2/adenovirus E1B 19 kDa protein-interacting protein 1) (Transformation-related gene 8 protein) (TRG-8)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q12981
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q12981/entry
Mouse Swissprot No.
Q6QD59
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q6QD59
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q8VHI8
免疫原
Synthesized peptide derived from part region of human protein
特异性
SEC20 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. In addition, this protein is involved in vesicle transport into the endoplasmic reticulum. Alternative splicing of this gene results in four protein products with identical N- and C-termini. [provided by RefSeq, Mar 2011],
组织表达
Isoform 1 is highly expressed in heart, brain, liver skeletal muscle and pancreas. Isoform 3 is moderately expressed in placenta, lung and kidney. Isoform 4 is highly expressed in testis and small intestine.
细胞定位
Endoplasmic reticulum membrane ; Single-pass type IV membrane protein . Mitochondrion membrane ; Single-pass type IV membrane protein . Localization to the mitochondrion is regulated by RNF186. .
信号通路
SNARE interactions in vesicular transport;
功能
alternative products:Additional isoforms seem to exist,function:SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. Required for maintenance of ER network. Implicated in the suppression of cell death.,miscellaneous:Silencing of BNIP1 disrupts ER morphology.,similarity:Belongs to the SEC20 family.,subunit:Component of a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L and SEC22B. Interacts directly with STX18, RINT1/TIP20L and NAPA. Interacts with ZW10 through RINT1. Interacts with BCL2 and adenovirus E1B 19 kDa protein.,tissue specificity:High levels of isoform 1 in heart, brain, liver skeletal muscle and pancreas. Moderate levels of isoform 3 in placenta, lung and kidney. High levels of isoform 4 in testis and small intestine.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
