产品名称
DOC10 Rabbit Polyclonal Antibody
基因名称
DOCK10 KIAA0694 ZIZ3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/55619
Human Swissprot No.
Q96BY6
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96BY6/entry
Mouse Swissprot No.
Q8BZN6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BZN6
免疫原
Synthesized peptide derived from human DOC10 AA range: 2051-2101
特异性
This antibody detects endogenous levels of DOC10 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family are guanosine nucleotide exchange factors for Rho GTPases and defined by the presence of conserved DOCK-homology regions. The encoded protein belongs to the D (or Zizimin) subfamily of DOCK proteins, which also contain an N-terminal pleckstrin homology domain. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Mar 2014],
组织表达
Expressed at low level in brain and lung. Isoform 1 is enriched in normal T-cells, isoform 3 is enriched in normal B-cells and chronic lymphocytic leukemia (CLL) B-cells.
细胞定位
Nucleus . Cytoplasm . Cell projection, dendritic spine .
功能
domain:The DHR-2 domain may mediate some GEF activity.,function:Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP.,similarity:Belongs to the DOCK family.,similarity:Contains 1 DHR-1 (CZH-1) domain.,similarity:Contains 1 DHR-2 (CZH-2) domain.,similarity:Contains 1 PH domain.,tissue specificity:Expressed at low level in brain and lung.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
