产品名称
VANG2 Rabbit Polyclonal Antibody
基因名称
VANGL2 KIAA1215 STB1
蛋白名称
Vang-like protein 2 (Loop-tail protein 1 homolog) (Strabismus 1) (Van Gogh-like protein 2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9ULK5
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9ULK5/entry
Mouse Swissprot No.
Q91ZD4
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q91ZD4
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P84889
免疫原
Synthesized peptide derived from part region of human protein
特异性
VANG2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a membrane protein involved in the regulation of planar cell polarity, especially in the stereociliary bundles of the cochlea. The encoded protein transmits directional signals to individual cells or groups of cells in epithelial sheets. This protein is also involved in the development of the neural plate. [provided by RefSeq, Sep 2011],
细胞定位
Cell membrane ; Multi-pass membrane protein .
功能
function:Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process.,similarity:Belongs to the Vang family.,subunit:Interacts through its C-terminal region with the N-terminal half of DVL1, DVL2 and DVL3. The PDZ domain of DVL1, DVL2 and DVL3 is required for the interaction. Also interacts with the PDZ domains of MAGI3, SCRIB/SCRB1 and FZD3.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
