产品名称
GBP2 Rabbit Polyclonal Antibody (Center)
别名
Interferon-induced guanylate-binding protein 2, GTP-binding protein 2, GBP-2, HuGBP-2, Guanine nucleotide-binding protein 2, GBP2
存储缓冲液
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) New type preservative N. This antibody is purified through a protein A column, followed by peptide affinity purification.
Human Gene ID
NP_004111.2
Human Swissprot No.
P32456
特异性
This GBP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 192-220 amino acids from the Central region of human GBP2.
运输及保存条件
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
背景介绍
Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product.
细胞定位
Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus membrane. Membrane; Lipid- anchor. Note=GBP2-GBP5 dimers localize to the Golgi apparatus.
功能
Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP (PubMed:
8706832). Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).
