产品名称
GPR4 Rabbit Polyclonal Antibody (Center)
别名
G-protein coupled receptor 4, G-protein coupled receptor 19, GPR4, GPR19
存储缓冲液
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) New type preservative N. This antibody is purified through a protein A column, followed by peptide affinity purification.
Human Gene ID
NP_005273.1
Human Swissprot No.
P46093
特异性
This GPR4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 196-224 amino acids from the Central region of human GPR4.
运输及保存条件
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
背景介绍
Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production.
细胞定位
Cell membrane; Multi-pass membrane protein
功能
Proton-sensing G-protein coupled receptor couples to multiple intracellular signaling pathways, including GNAS/cAMP, GNAQ/phospholipase C (PLC), and GNA12/GNA13/Rho pathways (PubMed:
12955148, PubMed:
17462861, PubMed:
22110680, PubMed:
20211729). Acidosis-induced GPR4 activation increases paracellular gap formation and permeability of vascular endothelial cells through the GNA12/GNA13/Rho GTPase signaling pathway (PubMed:
32058960). In the brain may mediate central respiratory sensitivity to CO(2)H(+) (By similarity).