BD-PN1508

VATB2 Rabbit Polyclonal Antibody

常规抗体

ATP6V1B2 ATP6B2 VPP3

V-type proton ATPase subunit B, brain isoform (V-ATPase subunit B 2) (Endomembrane proton pump 58 kDa subunit) (HO57) (Vacuolar proton pump subunit B 2)

WB

Human,Rat,Mouse,Swine

1 mg/ml

Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.

526

P21281

https://www.uniprot.org/uniprotkb/P21281/entry

P62814

http://www.uniprot.org/uniprot/P62814

P62815

http://www.uniprot.org/uniprot/O54941P62815

Synthesized peptide derived from part region of human protein

VATB2 Polyclonal Antibody detects endogenous levels of protein.

WB 1:500-2000 ELISA 1:5000-20000

56kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts. [provided by RefSeq, Jul 2008],

Kidney; localizes to early distal nephron, encompassing thick ascending limbs and distal convoluted tubules (at protein level).

Apical cell membrane . Melanosome . Cytoplasm . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Peripheral membrane protein . Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Peripheral membrane protein . Identified by mass spectrometry in melanosome fractions from stage I to stage IV. .

Oxidative phosphorylation;Vibrio cholerae infection;Epithelial cell signaling in Helicobacter pylori infection;

function:Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.,similarity:Belongs to the ATPase alpha/beta chains family.,subcellular location:Endomembrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:V-ATPase is an heteromultimeric enzyme composed of a peripheral catalytic V1 complex (main components: subunits A, B, C, D, E, and F) attached to an integral membrane V0 proton pore complex (main component: the proteolipid protein).,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.