产品名称
FCGR2A Rabbit Polyclonal Antibody (C-term)
别名
Low affinity immunoglobulin gamma Fc region receptor II-a, IgG Fc receptor II-a, CDw32, Fc-gamma RII-a, Fc-gamma-RIIa, FcRII-a, CD32, FCGR2A, CD32, FCG2, FCGR2A1, IGFR2
存储缓冲液
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) New type preservative N. This antibody is purified through a protein A column, followed by peptide affinity purification.
Human Gene ID
NP_001129691.1;NP_067674.2
Human Swissprot No.
P12318
特异性
This FCGR2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 255-282 amino acids from the C-terminal region of human FCGR2A.
稀释度
WB~~1:1000;FC~~1:10~50
运输及保存条件
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
背景介绍
FCGR2A is one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants.
组织表达
Found on monocytes, neutrophils and eosinophil platelets
细胞定位
Cell membrane; Single-pass type I membrane protein
功能
Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens.