产品名称
MME Rabbit Polyclonal Antibody (Center)
别名
Neprilysin, Atriopeptidase, Common acute lymphocytic leukemia antigen, CALLA, Enkephalinase, Neutral endopeptidase 2411, NEP, Neutral endopeptidase, Skin fibroblast elastase, SFE, CD10, MME, EPN
存储缓冲液
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) New type preservative N. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Human Gene ID
NP_000893.2;NP_009218.2;NP_009219.2;NP_009220.2
Human Swissprot No.
P08473
特异性
This MME antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 274-302 amino acids from the Central region of human MME.
稀释度
WB~~1:1000;IF~~1:10~50
运输及保存条件
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
背景介绍
MME is a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a oprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin.
细胞定位
Cell membrane; Single-pass type II membrane protein
功能
Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:
15283675, PubMed:
8168535). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:
17101991). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:
15283675). Involved in the degradation of atrial natriuretic factor (ANF) and brain natriuretic factor (BNP(1- 32)) (PubMed:
2531377, PubMed:
2972276, PubMed:
16254193). Displays UV- inducible elastase activity toward skin preelastic and elastic fibers (PubMed:
20876573).
