产品名称
UB2R2 Rabbit Polyclonal Antibody
蛋白名称
Ubiquitin-conjugating enzyme E2 R2 (EC 6.3.2.19) (Ubiquitin carrier protein R2) (Ubiquitin-conjugating enzyme E2-CDC34B) (Ubiquitin-protein ligase R2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q712K3
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q712K3/entry
Mouse Swissprot No.
Q6ZWZ2
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q6ZWZ2
免疫原
Synthesized peptide derived from part region of human protein
特异性
UB2R2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. This gene encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation. [provided by RefSeq, Jul 2008],
组织表达
Carcinoma,Ovary,Testis,
信号通路
Ubiquitin mediated proteolysis;
功能
catalytic activity:ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.,function:Catalyzes the covalent attachment of ubiquitin to other proteins. May be involved in degradation of katenin.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the ubiquitin-conjugating enzyme family.,subunit:When phosphorylated, interacts with beta-TrCP (BTRC).,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
