产品名称
STEA2 Rabbit Polyclonal Antibody (Center)
别名
Metalloreductase STEAP2, 1161-, Prostate cancer-associated protein 1, Protein up-regulated in metastatic prostate cancer, PUMPCn, Six-transmembrane epithelial antigen of prostate 2, SixTransMembrane protein of prostate 1, STEAP2, PCANAP1, STAMP1
存储缓冲液
Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Human Gene ID
NP_001035755.1;NP_001035756.1;NP_001231873.1;NP_001231875.1;NP_694544.2
Human Swissprot No.
Q8NFT2
特异性
This STEAP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 229-258 amino acids of human STEAP2.
运输及保存条件
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
背景介绍
This gene is a member of the STEAP family and encodes a
multi-pass membrane protein that localizes to the Golgi complex,
the plasma membrane, and the vesicular tubular structures in the
cytosol. A highly similar protein in mouse has both ferrireductase
and cupric reductase activity, and stimulates the cellular uptake
of both iron and copper in vitro. Increased transcriptional
expression of the human gene is associated with prostate cancer
progression. Alternate transcriptional splice variants, encoding
different isoforms, have been characterized.
组织表达
Expressed at high levels in prostate and at significantly lower levels in heart, brain, kidney, pancreas, and ovary.
细胞定位
Endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein
功能
Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity).
