产品名称
UBXN4 Rabbit Polyclonal Antibody
基因名称
UBXN4 KIAA0242 UBXD2 UBXDC1
蛋白名称
UBX domain-containing protein 4 (Erasin) (UBX domain-containing protein 2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q92575
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q92575/entry
Mouse Swissprot No.
Q8VCH8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8VCH8
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q5HZY0
免疫原
Synthesized peptide derived from part region of human protein
特异性
UBXN4 Polyclonal Antibody detects endogenous levels of protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
UBXD2 is an integral membrane protein of the endoplasmic reticulum (ER) that binds valosin-containing protein (VCP; MIM 601023) and promotes ER-associated protein degradation (ERAD) (Liang et al., 2006 [PubMed 16968747]).[supplied by OMIM, Mar 2008],
组织表达
Expressed in many tissues, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Accumulates in Alzheimer disease-afflicted brains (at protein level).
细胞定位
Endoplasmic reticulum membrane ; Peripheral membrane protein . Nucleus envelope . Both the N- and the C-terminus face the cytosol. Also found in the nucleus envelope contiguous to the ER. .
功能
domain:The transmembrane domain also contains the signal for ER targeting.,domain:The UBX domain is required for interaction with VCP.,function:Involved in endoplasmic reticulum-associated protein degradation (ERAD).,induction:By ER stress-inducing reagents, such as tunicamycin, thapsigargin, DTT and the calcium ionophore A23187 (at protein level).,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 UBX domain.,subcellular location:Both the N- and the C-terminus face the cytosol; also found in the nucleus envelope contiguous to the ER.,subunit:Directly interacts with VCP.,tissue specificity:Expressed in many tissues, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Accumulates in Alzheimer disease-afflicted brains (at protein level).,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
