产品名称
HME2 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/2020
Human Swissprot No.
P19622
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P19622/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/13799
Mouse Swissprot No.
P09066
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P09066
免疫原
Synthesized peptide derived from human HME2 AA range: 225-275
特异性
This antibody detects endogenous levels of HME2 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. [provided by RefSeq, Jul 2008],
功能
disease:Genetic variations in EN2 may be associated with susceptibility to autism type 10 (AUTS10) [MIM:611016]. Autism is a neurodevelopmental disorder characterized by disturbance in language, perception and socialization. The disorder is classically defined by a triad of limited or absent verbal communication, a lack of reciprocal social interaction or responsiveness, and restricted, stereotypical and ritualized patterns of interests and behavior.,similarity:Belongs to the engrailed homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
