产品名称
Epsin2 Rabbit Polyclonal Antibody (N-term)
别名
Epsin-2, EPS-15-interacting protein 2, EPN2, KIAA1065
存储缓冲液
Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is purified through a protein A column, followed by peptide affinity purification.
Human Gene ID
NP_001096134.1;NP_055779.2;NP_683723.2
Human Swissprot No.
O95208
特异性
This Epsin2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-36 amino acids from the N-terminal region of human Epsin2.
运输及保存条件
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
背景介绍
Epsin2 plays a role in the formation of clathrin-coated invaginations and endocytosis. It binds to EPS15 (via the NPF repeat domain), as well as to AP-2 and clathrin (via the DPW repeat domain). The protein resides in the cytoplasm, in punctate structures throughout the cell, associated with clathrin-coated vesicles, and is particularly concentrated in the region of the Golgi complex. Highest expression is found in brain, with lower levels detected in lung and liver.
组织表达
Highest expression is found in brain. Detected at lower levels in lung and liver.
细胞定位
Cytoplasm. Cytoplasmic vesicle, clathrin-coated vesicle. Note=In punctate structures throughout the cell, associated with clathrin-coated vesicles, and particularly concentrated in the region of the Golgi complex
功能
Plays a role in the formation of clathrin-coated invaginations and endocytosis.
