产品名称
CNBP Rabbit Polyclonal Antibody (Center)
别名
Cellular nucleic acid-binding protein, CNBP, Zinc finger protein 9, CNBP, RNF163, ZNF9
存储缓冲液
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) New type preservative N. This antibody is purified through a protein A column, followed by peptide affinity purification.
Human Gene ID
NP_001120664.1;NP_001120665.1;NP_001120666.1;NP_001120668.1;NP_003409.1
Human Swissprot No.
P62633
特异性
This CNBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 91-118 amino acids from the Central region of human CNBP.
稀释度
IHC-P~~1:100~500;WB~~1:1000
运输及保存条件
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
背景介绍
This gene encodes a nucleic-acid binding protein with
seven zinc-finger domains. The protein has a preference for binding
single stranded DNA and RNA. The protein functions in
cap-independent translation of ornithine decarboxylase mRNA, and
may also function in sterol-mediated transcriptional regulation. A
CCTG expansion in the first intron of this gene results in myotonic
dystrophy type 2. Multiple transcript variants encoding different
isoforms have been found for this gene.
组织表达
Expressed in the liver, kidney, spleen, testis, lung, muscle and adrenal glands.
细胞定位
Nucleus {ECO:0000250|UniProtKB:P53996}. Cytoplasm. Endoplasmic reticulum {ECO:0000250|UniProtKB:P53996} [Isoform 2]: Cytoplasm [Isoform 5]: Cytoplasm [Isoform 8]: Cytoplasm
功能
Single-stranded DNA-binding protein that preferentially binds to the sterol regulatory element (SRE) sequence 5'-GTGCGGTG-3', and thereby mediates transcriptional repression (PubMed:
2562787). Has a role as transactivator of the Myc promoter (By similarity). Binds single-stranded RNA in a sequence-specific manner (By similarity).
