产品名称
TSC2 Rabbit Polyclonal Antibody (Center S1418/S1420)
别名
Tuberin, Tuberous sclerosis 2 protein, TSC2, TSC4
存储缓冲液
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) New type preservative N. This antibody is purified through a protein A column, followed by peptide affinity purification.
Human Gene ID
NP_000539.2;NP_001070651.1;NP_001107854.1
Human Swissprot No.
P49815
特异性
This TSC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1397-1426 amino acids from the Central region of human TSC2.
稀释度
IHC-P~~1:100~500;WB~~1:1000
运输及保存条件
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
背景介绍
Mutations in this gene lead to tuberous sclerosis complex.
Its gene product is believed to be a tumor suppressor and is able
to stimulate specific GTPases. The protein associates with hamartin
in a cytosolic complex, possibly acting as a chaperone for
hamartin. Alternative splicing results in multiple transcript
variants encoding different isoforms.
组织表达
Liver, brain, heart, lymphocytes, fibroblasts, biliary epithelium, pancreas, skeletal muscle, kidney, lung and placenta
细胞定位
Cytoplasm. Membrane; Peripheral membrane protein. Note=At steady state found in association with membranes
功能
In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (PubMed:
12271141, PubMed:
28215400). Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:
15340059). May also play a role in microtubule-mediated protein transport (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity).
