产品名称
CLDN14 Rabbit Polyclonal Antibody (C-term)
存储缓冲液
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) New type preservative N. This antibody is purified through a protein A column, followed by peptide affinity purification.
Human Gene ID
NP_001139549.1;NP_001139550.1;NP_001139551.1;NP_036262.1;NP_652763.1
Human Swissprot No.
O95500
特异性
This CLDN14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 172-200 amino acids from the C-terminal region of human CLDN14.
运输及保存条件
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
背景介绍
Tight junctions represent one mode of cell-to-cell
adhesion in epithelial or endothelial cell sheets, forming
continuous seals around cells and serving as a physical barrier to
prevent solutes and water from passing freely through the
paracellular space. These junctions are comprised of sets of
continuous networking strands in the outwardly facing cytoplasmic
leaflet, with complementary grooves in the inwardly facing
extracytoplasmic leaflet. The protein encoded by this gene, a
member of the claudin family, is an integral membrane protein and a
component of tight junction strands. The encoded protein also binds
specifically to the WW domain of Yes-associated protein. Defects in
this gene are the cause of an autosomal recessive form of
nonsyndromic sensorineural deafness. It is also reported that four
synonymous variants in this gene are associated with kidney stones
and reduced bone mineral density. Several transcript variants
encoding the same protein have been found for this gene. [provided
by RefSeq].
组织表达
Liver, kidney. Also found in ear.
细胞定位
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein
功能
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
