产品名称
HDAC1 Rabbit Polyclonal Antibody (Center S423)
别名
Histone deacetylase 1, HD1, HDAC1, RPD3L1
存储缓冲液
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) New type preservative N. This antibody is purified through a protein A column, followed by peptide affinity purification.
Human Gene ID
NP_004955.2
Human Swissprot No.
Q13547
特异性
This HDAC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 402-430 amino acids from the Central region of human HDAC1.
稀释度
WB~~1:1000;IF~~1:10~50
运输及保存条件
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
背景介绍
Histone acetylation and deacetylation, catalyzed by
multisubunit complexes, play a key role in the regulation of
eukaryotic gene expression. The protein encoded by this gene
belongs to the histone deacetylase/acuc/apha family and is a
component of the histone deacetylase complex. It also interacts
with retinoblastoma tumor-suppressor protein and this complex is a
key element in the control of cell proliferation and
differentiation. Together with metastasis-associated protein-2, it
deacetylates p53 and modulates its effect on cell growth and
apoptosis.
组织表达
Ubiquitous, with higher levels in heart, pancreas and testis, and lower levels in kidney and brain
功能
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation.
