产品名称
DRD2 Rabbit Polyclonal Antibody (C-term)
别名
D(2) dopamine receptor, Dopamine D2 receptor, DRD2
存储缓冲液
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) New type preservative N. This antibody is purified through a protein A column, followed by peptide affinity purification.
Human Gene ID
NP_000786.1;NP_057658.2
Human Swissprot No.
P14416
特异性
This DRD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 307-336 amino acids from the C-terminal region of human DRD2.
运输及保存条件
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
背景介绍
This gene encodes the D2 subtype of the dopamine receptor.
This G-protein coupled receptor inhibits adenylyl cyclase activity.
A missense mutation in this gene causes myoclonus dystonia; other
mutations have been associated with schizophrenia. Alternative
splicing of this gene results in two transcript variants encoding
different isoforms. A third variant has been described, but it has
not been determined whether this form is normal or due to aberrant
splicing.
组织表达
[Isoform 1]: Expressed in the anterior pituitary gland.
细胞定位
Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein
功能
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (PubMed:
21645528). Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5 (By similarity).
