产品名称
CREB3L4 Rabbit Polyclonal Antibody (C-term)
别名
Cyclic AMP-responsive element-binding protein 3-like protein 4, cAMP-responsive element-binding protein 3-like protein 4, Androgen-induced basic leucine zipper protein, AIbZIP, Attaching to CRE-like 1, ATCE1, Cyclic AMP-responsive element-binding protein 4, CREB-4, cAMP-responsive element-binding protein 4, Transcript induced in spermiogenesis protein 40, Tisp40, hJAL, Processed cyclic AMP-responsive element-binding protein 3-like protein 4, CREB3L4, AIBZIP, CREB4, JAL
存储缓冲液
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) New type preservative N. This antibody is purified through a protein A column, followed by peptide affinity purification.
Human Gene ID
NP_001242907.1;NP_001242908.1;NP_001242909.1;NP_001242910.1;NP_570968.1
Human Swissprot No.
Q8TEY5
特异性
This CREB3L4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 338-366 amino acids from the C-terminal region of human CREB3L4.
运输及保存条件
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
背景介绍
cAMP response element-binding (CREB) proteins are a family
of mammalian transcription activators. For further background
information on CREB proteins, see CREB1 (MIM 123810).[supplied by
OMIM].
组织表达
According to PubMed:11830526, exclusively expressed in the prostate. Expressed in breast and prostate cancer cell lines Expressed in prostatic luminal epithelial cells (at protein level) Expression is significantly more abundant in prostate cancer than in benign prostatic tissue (prostatic hyperplasia). According to PubMed:12111373, also expressed in brain, pancreas and skeletal muscle, and at lower levels in small intestine, testis, leukocyte and thymus
细胞定位
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single- pass type II membrane protein. Note=May also be located in Golgi apparatus
功能
Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements (By similarity).
