产品名称
ELK3 Rabbit Polyclonal Antibody (N-term)
别名
ETS domain-containing protein Elk-3, ETS-related protein ERP, ETS-related protein NET, Serum response factor accessory protein 2, SAP-2, SRF accessory protein 2, ELK3, NET, SAP2
存储缓冲液
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) New type preservative N. This antibody is purified through a protein A column, followed by peptide affinity purification.
Human Gene ID
NP_005221.2
Human Swissprot No.
P41970
特异性
This ELK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 98-126 amino acids from the N-terminal region of human ELK3.
运输及保存条件
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
背景介绍
The protein encoded by this gene is a member of the
ETS-domain transcription factor family and the ternary complex
factor (TCF) subfamily. Proteins in this subfamily regulate
transcription when recruited by serum response factor to bind to
serum response elements. This protein is activated by
signal-induced phosphorylation; studies in rodents suggest that it
is a transcriptional inhibitor in the absence of Ras, but activates
transcription when Ras is present.
功能
May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element.