产品名称
KRT28 Rabbit Polyclonal Antibody (C-term)
别名
Keratin, type I cytoskeletal 28, Cytokeratin-28, CK-28, Keratin-25D, K25D, Keratin-28, K28, Type I inner root sheath-specific keratin-K25irs4, KRT28 (
HGNC:30842)
存储缓冲液
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) New type preservative N. This antibody is purified through a protein A column, followed by peptide affinity purification.
Human Gene ID
NP_853513.2
Human Swissprot No.
Q7Z3Y7
特异性
This KRT28 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 432-460 amino acids from the C-terminal region of human KRT28.
运输及保存条件
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
背景介绍
This gene encodes a member of the type I (acidic) keratin
family, which belongs to the superfamily of intermediate filament
(IF) proteins. Keratins are heteropolymeric structural proteins
which form the intermediate filament. These filaments, along with
actin microfilaments and microtubules, compose the cytoskeleton of
epithelial cells. The type I keratin genes are clustered in a
region of chromosome 17q12-q21.
组织表达
Strongly expressed in skin and scalp, and weak expression observed in thymus. In the hair follicle, expressed in Henle layer, Huxley layer and in the irs cuticle. Expression extends from the bulb region up to the point of differentiation into the three layers Also present in the medulla of beard hair (at protein level)
细胞定位
Cytoplasm {ECO:0000250|UniProtKB:A6BLY7}.
功能
Essential for the proper assembly of types I and II keratin protein complexes and the formation of keratin intermediate filaments in the inner root sheath (irs).
