BD-PB4348-COPS2 Rabbit Polyclonal Antibody (N-term)-现货抗体产品库武汉枢密脑科学技术有限公司

COPS2 Rabbit Polyclonal Antibody (N-term)

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产品基本信息

产品货号

BD-PB4348

产品名称

COPS2 Rabbit Polyclonal Antibody (N-term)

别名

COP9 signalosome complex subunit 2, SGN2, Signalosome subunit 2, Alien homolog, JAB1-containing signalosome subunit 2, Thyroid receptor-interacting protein 15, TR-interacting protein 15, TRIP-15, COPS2, CSN2, TRIP15

类别

常规抗体

推荐应用

反应种属

Human, Rat, Mouse

存储缓冲液

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) New type preservative N. This antibody is purified through a protein A column, followed by peptide affinity purification.

Human Gene ID

NP_001137359.1;NP_004227.1

Human Swissprot No.

P61201

特异性

This COPS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human COPS2.

稀释度

IHC-P~~1:100~500;IF~~1:25;WB~~1:1000

预测分子量

52kDa

运输及保存条件

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

宿主

Rabbit

同种型

Rabbit IgG

背景介绍

Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.

细胞定位

Cytoplasm. Nucleus

功能

期货

现货

Immunohistochemical analysis of paraffin-embedded H. skin section using COPS2 Antibody (N-term). BD-PB4348 was diluted at 1:25 dilution. A undiluted biotinylated goat polyvalent antibody was used as the secondary, followed by DAB staining.

Fluorescent image of Hela cells stained with COPS2 Antibody (N-term). BD-PB4348 was diluted at 1:25 dilution. An Alexa Fluor 488-conjugated goat anti-rabbit lgG at 1:400 dilution was used as the secondary antibody (green). Cytoplasmic actin was counterstained with Alexa Fluor® 555 conjugated with Phalloidin (red).

Western blot analysis of lysates from Hela, K562, U-251 MG cell line, mouse brain tissue, mouse F9 cell line, rat brain tissue (from left to right), using COPS2 Antibody (N-term)at 1:10000 dilution was used as the secondary antibody. Lysates at 20ug per lane.

COPS2 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.