产品名称
DNAJB11 Rabbit Polyclonal Antibody (N-term)
别名
DnaJ homolog subfamily B member 11, APOBEC1-binding protein 2, ABBP-2, DnaJ protein homolog 9, ER-associated DNAJ, ER-associated Hsp40 co-chaperone, Endoplasmic reticulum DNA J domain-containing protein 3, ER-resident protein ERdj3, ERdj3, ERj3p, HEDJ, Human DnaJ protein 9, hDj-9, PWP1-interacting protein 4, DNAJB11, EDJ, ERJ3, HDJ9
存储缓冲液
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) New type preservative N. This antibody is purified through a protein A column, followed by peptide affinity purification.
Human Gene ID
NP_057390.1
Human Swissprot No.
Q9UBS4
特异性
This DNAJB11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-92 amino acids from the N-terminal region of human DNAJB11.
稀释度
WB~~1:1000;IHC-P~~1:100~500
运输及保存条件
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
背景介绍
DNAJB11 belongs to the evolutionarily conserved DNAJ/HSP40
family of proteins, which regulate molecular chaperone activity by
stimulating ATPase activity. DNAJ proteins may have up to 3
distinct domains: a conserved 70-amino acid J domain, usually at
the N terminus; a glycine/phenylalanine (G/F)-rich region; and a
C-terminal cysteine-rich region (Ohtsuka and Hata, 2000 [PubMed
11147971]).
细胞定位
Endoplasmic reticulum lumen Note=Associated with the ER membrane in a C-terminally epitope-tagged construct
功能
As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins (PubMed:
10827079, PubMed:
15525676, PubMed:
29706351). Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed (PubMed:
15525676). May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity (PubMed:
10827079). It is necessary for maturation and correct trafficking of PKD1 (PubMed:
29706351).
