产品名称
SOX15 Rabbit Polyclonal Antibody (Center)
别名
Protein SOX-15, Protein SOX-12, Protein SOX-20, SOX15, SOX12, SOX20, SOX26, SOX27
存储缓冲液
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) New type preservative N. This antibody is purified through a protein A column, followed by peptide affinity purification.
Human Gene ID
NP_008873.1
Human Swissprot No.
O60248
特异性
This SOX15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 96-125 amino acids from the Central region of human SOX15.
稀释度
WB~~1:1000;IHC-P~~1:100~500
运输及保存条件
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
背景介绍
This gene encodes a member of the SOX (SRY-related
HMG-box) family of transcription factors involved in the regulation
of embryonic development and in the determination of the cell fate.
The encoded protein may act as a transcriptional regulator after
forming a protein complex with other proteins. [provided by
RefSeq].
组织表达
Widely expressed in fetal and adult tissues examined, highest level found in fetal spinal cord and adult brain and testis.
细胞定位
Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
功能
Transcription factor that binds to DNA at the 5'-AACAATG-3' consensus sequence (By similarity). Acts as a transcriptional activator and repressor (By similarity). Binds synergistically with POU5F1 (OCT3/4) to gene promoters (By similarity). Binds to the FOXK1 promoter and recruits FHL3, resulting in transcriptional activation of FOXK1 which leads to myoblast proliferation (By similarity). Acts as an inhibitor of myoblast differentiation via transcriptional repression which leads to down-regulation of the muscle-specific genes MYOD and MYOG (By similarity). Involved in trophoblast giant cell differentiation via enhancement of HAND1 transcriptional activity (By similarity). Regulates transcription of HRC via binding to it proximal enhancer region (By similarity). Involved in skeletal muscle regeneration (By similarity). Also plays a role in the development of myogenic precursor cells (By similarity).
