产品名称
RNH1 Rabbit Polyclonal Antibody (C-term)
别名
Ribonuclease inhibitor, Placental ribonuclease inhibitor, Placental RNase inhibitor, Ribonuclease/angiogenin inhibitor 1, RAI, RNH1, PRI, RNH
存储缓冲液
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) New type preservative N. This antibody is purified through a protein A column, followed by peptide affinity purification.
Human Gene ID
NP_002930.2;NP_976317.1;NP_976318.1;NP_976319.1;NP_976320.1;NP_976321.1;NP_976322.1;NP_976323.1
Human Swissprot No.
P13489
特异性
This RNH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 425-454 amino acids from the C-terminal region of human RNH1.
稀释度
WB~~1:1000;IF~~1:10~50
运输及保存条件
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
背景介绍
Placental ribonuclease inhibitor (PRI) is a member of a
family of proteinaceous cytoplasmic RNase inhibitors that occur in
many tissues and bind to both intracellular and extracellular
RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In
addition to control of intracellular RNases, the inhibitor may have
a role in the regulation of angiogenin (MIM 105850). Ribonuclease
inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a
latent form. Since neutral and alkaline ribonucleases probably play
a critical role in the turnover of RNA in eukaryotic cells, RNH may
be essential for control of mRNA turnover; the interaction of
eukaryotic cells with ribonuclease may be reversible in
vivo.
功能
Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis.