产品名称
JMJD2C Rabbit Polyclonal Antibody (C-term)
别名
Lysine-specific demethylase 4C, 11411-, Gene amplified in squamous cell carcinoma 1 protein, GASC-1 protein, JmjC domain-containing histone demethylation protein 3C, Jumonji domain-containing protein 2C, KDM4C, GASC1, JHDM3C, JMJD2C, KIAA0780
存储缓冲液
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) New type preservative N. This antibody is purified through a protein A column, followed by peptide affinity purification.
Human Gene ID
NP_001140166.1;NP_001140167.1;NP_001140168.1;NP_055876.2
Human Swissprot No.
Q9H3R0
特异性
This JMJD2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1023-1056 amino acids from the C-terminal region of human JMJD2C.
运输及保存条件
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
背景介绍
This gene is a member of the Jumonji domain 2 (JMJD2)
family and encodes a protein with one JmjC domain, one JmjN domain,
two PHD-type zinc fingers, and two Tudor domains. This nuclear
protein functions as a trimethylation-specific demethylase,
converting specific trimethylated histone residues to the
dimethylated form. Chromosomal aberrations and increased
transcriptional expression of this gene are associated with
esophageal squamous cell carcinoma. Alternative splicing results in
multiple transcript variants.
组织表达
Overexpressed in several esophageal squamous cell carcinomas (ESCs).
细胞定位
Nucleus {ECO:0000255|PROSITE-ProRule:PRU00537}.
功能
Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.
