BD-PB4306-STRA8 Rabbit Polyclonal Antibody (C-term)-现货抗体产品库武汉枢密脑科学技术有限公司

STRA8 Rabbit Polyclonal Antibody (C-term)

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产品基本信息

产品货号

BD-PB4306

产品名称

STRA8 Rabbit Polyclonal Antibody (C-term)

别名

Stimulated by retinoic acid gene 8 protein homolog, STRA8 {ECO:0000312|EMBL:AAP471631}

类别

常规抗体

推荐应用

反应种属

Human

存储缓冲液

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) New?type?preservative?N. This antibody is purified through a protein A column, followed by peptide affinity purification.

Human Gene ID

NP_872295.1

Human Swissprot No.

Q7Z7C7

特异性

This STRA8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 286-315 amino acids from the C-terminal region of human STRA8.

稀释度

WB 1:2000

预测分子量

37kDa

运输及保存条件

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

宿主

Rabbit

同种型

Rabbit IgG

背景介绍

This gene encodes a retinoic acid-responsive protein. A homologous protein in mouse has been shown to be involved in the regulation of meiotic initiation in both spermatogenesis and oogenesis, though feature differences between the mouse and human proteins suggest that these homologs are not entirely functionally equivalent. It is thought that this gene may play a role in spermatogenesis in humans.

组织表达

Expressed specifically in testis and fetal ovaries.

细胞定位

Cytoplasm {ECO:0000250|UniProtKB:P70278}. Nucleus {ECO:0000250|UniProtKB:P70278}. Note=Shuttles between nucleus and cytoplasm. Nuclear export is XPO1-dependent {ECO:0000250|UniProtKB:P70278}

功能

Meiosis-inducer required for the transition into meiosis for both female and male germ cells. In female germ cells, acts downstream of ZGLP1 as a key effector of the meiotic program: required for premeiotic DNA replication and subsequent events in meiotic prophase. During spermatogenesis, next to its role in meiotic initiation, promotes (but is not required for) spermatogonial differentiation. In complex with MEIOSIN, directly activates the transcription of a subset of critical meiotic genes playing a central role in cell-cycle switching from mitosis to meiosis.

期货

现货

Immunohistochemical analysis of BD-PB4306 on paraffin-embedded human lung tissue was performed on the Leica??BOND RXm. Tissue was fixed with formaldehyde at room temperature. Heat induced epitope retrieval was performed by EDTA buffer (pH9. 0). Samples were incubated with primary antibody(1:250) for 15min at room temperature. Leica Bond Polymer Refine Detection was used as the secondary antibody.

All lanes : Anti-STRA8 Antibody (C-term) at 1:2000 dilution Lane 1: 293 whole cell lysate Lane 2: LNCaP whole cell lysate Lane 3: PC-3 whole cell lysate Lane 4: DU145 whole cell lysate Lane 5: SK-OV-3 whole cell lysate Lane 6: OVCAR3 whole cell lysate Lysates/proteins at 20 μg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 37 kDa Blocking/Dilution buffer: 5% NFDM/TBST.