产品名称
CTLA4 Rabbit Polyclonal Antibody (N-term)
别名
Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4, CTLA-4, CD152, CTLA4, CD152
存储缓冲液
Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Human Gene ID
NP_001032720.1;NP_005205.2
Human Swissprot No.
P16410
特异性
This IDDM12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 50-78 amino acids of human IDDM12.
运输及保存条件
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
背景介绍
CTLA4 is a member of the immunoglobulin superfamily
and encodes a protein which transmits an inhibitory signal to T
cells. The protein contains a V domain, a transmembrane domain, and
a cytoplasmic tail. Alternate transcriptional splice variants,
encoding different isoforms, have been characterized. The
membrane-bound isoform functions as a homodimer interconnected by a
disulfide bond, while the soluble isoform functions as a monomer.
Mutations in this gene have been associated with insulin-dependent
diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac
disease, systemic lupus erythematosus, thyroid-associated
orbitopathy, and other autoimmune diseases.
组织表达
Widely expressed with highest levels in lymphoid tissues. Detected in activated T-cells where expression levels are 30- to 50-fold less than CD28, the stimulatory coreceptor, on the cell surface following activation.
细胞定位
Cell membrane; Single-pass type I membrane protein. Note=Exists primarily an intracellular antigen whose surface expression is tightly regulated by restricted trafficking to the cell surface and rapid internalization
功能
Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
