产品名称
MME Rabbit Polyclonal Antibody (Center)
别名
Neprilysin, Atriopeptidase, Common acute lymphocytic leukemia antigen, CALLA, Enkephalinase, Neutral endopeptidase 2411, NEP, Neutral endopeptidase, Skin fibroblast elastase, SFE, CD10, MME, EPN
存储缓冲液
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) New type preservative N. This antibody is purified through a protein A column, followed by peptide affinity purification.
Human Gene ID
NP_000893.2;NP_009218.2;NP_009219.2;NP_009220.2
Human Swissprot No.
P08473
特异性
This MME antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 721-747 amino acids from the C-terminal region of human MME.
稀释度
WB~~1:1000;IHC-P~~1:100~500
运输及保存条件
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
背景介绍
This gene encodes a common acute lymphocytic leukemia
antigen that is an important cell surface marker in the diagnosis
of human acute lymphocytic leukemia (ALL). This protein is present
on leukemic cells of pre-B phenotype, which represent 85% of cases
of ALL. This protein is not restricted to leukemic cells, however,
and is found on a variety of normal tissues. It is a glycoprotein
that is particularly abundant in kidney, where it is present on the
brush border of proximal tubules and on glomerular epithelium. The
protein is a neutral endopeptidase that cleaves peptides at the
amino side of hydrophobic residues and inactivates several peptide
hormones including glucagon, enkephalins, substance P, neurotensin,
oxytocin, and bradykinin. This gene, which encodes a 100-kD type II
transmembrane glycoprotein, exists in a single copy of greater than
45 kb. The 5' untranslated region of this gene is alternatively
spliced, resulting in four separate mRNA transcripts. The coding
region is not affected by alternative splicing. [provided by
RefSeq].
细胞定位
Cell membrane; Single-pass type II membrane protein
功能
Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:
15283675, PubMed:
8168535). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:
17101991). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:
15283675). Involved in the degradation of atrial natriuretic factor (ANF) and brain natriuretic factor (BNP(1- 32)) (PubMed:
2531377, PubMed:
2972276, PubMed:
16254193). Displays UV- inducible elastase activity toward skin preelastic and elastic fibers (PubMed:
20876573).
