产品名称
FASN (4C10) Mouse Monoclonal Antibody (Center)
别名
Fatty acid synthase, [Acyl-carrier-protein] S-acetyltransferase, [Acyl-carrier-protein] S-malonyltransferase, 3-oxoacyl-[acyl-carrier-protein] synthase, 3-oxoacyl-[acyl-carrier-protein] reductase, 3-hydroxyacyl-[acyl-carrier-protein] dehydratase, Enoyl-[acyl-carrier-protein] reductase, Oleoyl-[acyl-carrier-protein] hydrolase, FASN, FAS
存储缓冲液
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) New type preservative N. This antibody is purified through a protein G column, followed by dialysis against PBS.
Human Gene ID
NP_004095.4
Human Swissprot No.
P49327
特异性
This FASN antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 942-973 amino acids from the Central region of human FASN.
运输及保存条件
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
背景介绍
The enzyme encoded by this gene is a multifunctional
protein. Its main function is to catalyze the synthesis of
palmitate from acetyl-CoA and malonyl-CoA, in the presence of
NADPH, into long-chain saturated fatty acids. In some cancer cell
lines, this protein has been found to be fused with estrogen
receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused
in-frame with the C-terminus of ER-alpha.
组织表达
Ubiquitous. Prominent expression in brain, lung, liver and mammary gland.
细胞定位
Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV
功能
Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain.
