产品名称
B2M (16K17) Mouse Monoclonal Antibody
别名
Beta-2-microglobulin, Beta-2-microglobulin form pI 53, B2M
存储缓冲液
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) New type preservative N. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Human Gene ID
NP_004039.1
Human Swissprot No.
P61769
特异性
This B2M antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 10-39 amino acids from human B2M.
运输及保存条件
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
背景介绍
This gene encodes a serum protein found in association
with the major histocompatibility complex (MHC) class I heavy chain
on the surface of nearly all nucleated cells. The protein has a
predominantly beta-pleated sheet structure that can form amyloid
fibrils in some pathological conditions. A mutation in this gene
has been shown to result in hypercatabolic hypoproteinemia.
细胞定位
Secreted. Cell surface. Note=Detected in serum and urine (PubMed:1336137, PubMed:7554280). {ECO:0000269|PubMed:7554280, ECO:0000269|Ref.6}
功能
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:
25356553).
