产品名称
UBP10 Rabbit Polyclonal Antibody
蛋白名称
Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q14694
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q14694/entry
Mouse Swissprot No.
P52479
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P52479
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q3KR59
免疫原
Synthesized peptide derived from part region of human protein
特异性
UBP10 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and cytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and is inhibited by a protein in the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene. Several transcript variants, some protein-coding and others not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2013],
细胞定位
Cytoplasm . Nucleus . Early endosome . Cytoplasmic in normal conditions (PubMed:20096447). After DNA damage, translocates to the nucleus following phosphorylation by ATM (PubMed:20096447). .
功能
catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,function:Ubiquitin specific protease are required to remove ubiquitin from specific proteins or peptides to which ubiquitin is attached.,similarity:Belongs to the peptidase C19 family.,subunit:Interacts with G3BP, which may regulate its function.,tissue specificity:Widely expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
