BD-PB4207

RNF4 (17V1) Mouse Monoclonal Antibody

E3 ubiquitin-protein ligase RNF4, 6.3.2.-, RING finger protein 4, Small nuclear ring finger protein, Protein SNURF, RNF4, SNURF

常规抗体

WB

Human

P78317

This RNF4 antibody is generated from a mouse immunized with a recombinant protein from the human region of human RNF4.

WB~~1:2000

21kDa

IgG1,k

E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor- mediated transcriptional activation.

Widely expressed at low levels in many tissues; highly expressed in testis.

Cytoplasm. Nucleus. Nucleus, PML body. Nucleus, nucleoplasm

现货