产品名称
UBQL2 Rabbit Polyclonal Antibody
基因名称
UBQLN2 N4BP4 PLIC2 HRIHFB2157
蛋白名称
Ubiquilin-2 (Chap1) (DSK2 homolog) (Protein linking IAP with cytoskeleton 2) (PLIC-2) (hPLIC-2) (Ubiquitin-like product Chap1/Dsk2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9UHD9
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UHD9/entry
Mouse Swissprot No.
Q9QZM0
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9QZM0
免疫原
Synthesized peptide derived from part region of human protein
特异性
UBQL2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein. [provided by RefSeq, Oct 2009],
组织表达
Amygdala,B-cell,Fetal brain,Lung,
细胞定位
Cytoplasm . Nucleus . Membrane . Cytoplasmic vesicle, autophagosome . Colocalizes with a subset of proteasomes, namely those that are cytoskeleton associated or free in the cytosol. Associated with fibers in mitotic cells. .
功能
function:Increases the half-life of proteins destined to be degraded by the proteasome; may modulate proteasome-mediated protein degradation.,induction:Highly expressed in mitotic cells from metaphase to telophase. Expression in non-mitotic cells is very low.,similarity:Contains 1 UBA domain.,similarity:Contains 1 ubiquitin-like domain.,subcellular location:Where it colocalizes with the proteasome. Associated with fibers in mitotic cells.,subunit:Binds UBE3A and BTRC. Interacts with the 19S proteasome subunit.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
