BD-PB4198-ADAMTS4 (9T5) Mouse Monoclonal Antibody-现货抗体产品库武汉枢密脑科学技术有限公司

ADAMTS4 (9T5) Mouse Monoclonal Antibody

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产品基本信息

产品货号

BD-PB4198

产品名称

ADAMTS4 (9T5) Mouse Monoclonal Antibody

别名

A disintegrin and metalloproteinase with thrombospondin motifs 4, ADAM-TS 4, ADAM-TS4, ADAMTS-4, 3.4.24.82, ADMP-1, Aggrecanase-1, ADAMTS4, KIAA0688

类别

常规抗体

推荐应用

反应种属

Human

Human Swissprot No.

O75173

特异性

This ADAMTS4 antibody is generated from a mouse immunized with a recombinant protein from the human region of human ADAMTS4.

稀释度

WB~~1:8000

预测分子量

90kDa

同种型

IgG1,κ

背景介绍

Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.

组织表达

Expressed in brain, lung and heart (PubMed:23897278). Expressed at very low level in placenta and skeletal muscles (PubMed:23897278). Isoform 2: Detected in osteoarthritic synovium (PubMed:16723216, PubMed:23897278)

细胞定位

Secreted, extracellular space, extracellular matrix

期货

现货

Anti-ADAMTS4 Antibody at 1:8000 dilution + Recombinant protein Lysates/proteins at 20ng per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 90 kDa Blocking/Dilution buffer: 5% NFDM/TBST.