BD-PB4190

HACE1 (1K9) Mouse Monoclonal Antibody

E3 ubiquitin-protein ligase HACE1, 6.3.2.-, HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1, HACE1, KIAA1320

常规抗体

WB

Human, Rat, Mouse

Q8IYU2

This HACE1 antibody is generated from a mouse immunized with a recombinant protein from the human region of human HACE1.

WB~~1:2000

102kDa

IgG1,k

E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.

Expressed in multiple tissues including heart, brain and kidney.

Golgi apparatus, Golgi stack membrane. Cytoplasm. Endoplasmic reticulum. Note=A significant portion localizes to the endoplasmic reticulum. Targeted to Golgi membrane via its interaction with Rab proteins

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