BD-PB4189

DKK2 (7U16) Mouse Monoclonal Antibody

Dickkopf-related protein 2, Dickkopf-2, Dkk-2, hDkk-2, DKK2

常规抗体

WB

Human, Mouse

Q9UBU2

This DKK2 antibody is generated from a mouse immunized with a recombinant protein of human DKK2.

WB~~1:2000

28kDa

IgG1,k

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).

Expressed in heart, brain, skeletal muscle and lung

Secreted.

现货