BD-PB4185

ROS1 (18M17) Mouse Monoclonal Antibody

Proto-oncogene tyrosine-protein kinase ROS, 2.7.10.1, Proto-oncogene c-Ros, Proto-oncogene c-Ros-1, Receptor tyrosine kinase c-ros oncogene 1, c-Ros receptor tyrosine kinase, ROS1, MCF3, ROS

常规抗体

WB

Human, Rat, Mouse

P08922

This ROS1 antibody is generated from a mouse immunized with a recombinant protein of human ROS1.

WB~~1:4000;IHC~~1:250

264kDa

IgG1,k

Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2.

Expressed in brain. Expression is increased in primary gliomas.

Cell membrane; Single-pass type I membrane protein

现货