BD-PB4161

EIF2AK3 (3P3) Mouse Monoclonal Antibody

Eukaryotic translation initiation factor 2-alpha kinase 3, 2.7.11.1, PRKR-like endoplasmic reticulum kinase, Pancreatic eIF2-alpha kinase, HsPEK, EIF2AK3, PEK, PERK

常规抗体

WB

Human, Rat, Mouse

Q9NZJ5

This EIF2AK3 antibody is generated from a mouse immunized with a recombinant protein conjugated synthetic peptide between 530-850 amino acids from human EIF2AK3.

WB~~1:250-1:1000

125kDa

IgG1

Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function (By similarity).

Ubiquitous. A high level expression is seen in secretory tissues

Endoplasmic reticulum membrane; Single-pass type I membrane protein

现货