产品名称
PTN2 Rabbit Polyclonal Antibody
蛋白名称
Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (T-cell protein-tyrosine phosphatase) (TCPTP)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P17706
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P17706/entry
Mouse Swissprot No.
Q06180
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q06180
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P35233
免疫原
Synthesized peptide derived from part region of human protein
特异性
PTN2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. [provided by RefSeq, May 2011],
组织表达
Ubiquitously expressed. Isoform 2 is probably the major isoform. Isoform 1 is expressed in T-cells and in placenta.
细胞定位
[Isoform 1]: Endoplasmic reticulum . Endoplasmic reticulum-Golgi intermediate compartment . Targeted to the endoplasmic reticulum by its C-terminal hydrophobic region. .; [Isoform 2]: Nucleus. Cytoplasm. Cell membrane. Predominantly localizes to chromatin (By similarity). Able to shuttle between the nucleus and the cytoplasm and to dephosphorylate plasma membrane receptors (PubMed:9488479). Recruited by activated ITGA1 at the plasma membrane. .
功能
catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,similarity:Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.,similarity:Contains 1 tyrosine-protein phosphatase domain.,subunit:Interacts with FAM82A2.,tissue specificity:PTPA isoform is probably the major PTP expressed in human tissues. PTPB isoform was found in T-cells and in placenta.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
