产品名称
PTN18 Rabbit Polyclonal Antibody
蛋白名称
Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Brain-derived phosphatase)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q99952
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q99952/entry
Mouse Swissprot No.
Q61152
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q61152
免疫原
Synthesized peptide derived from part region of human protein
特异性
PTN18 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008],
组织表达
Expressed in brain, colon and several tumor-derived cell lines.
细胞定位
Nucleus . Cytoplasm .
功能
catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,function:Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues.,similarity:Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.,similarity:Contains 1 tyrosine-protein phosphatase domain.,subunit:Interacts with PSTPIP1.,tissue specificity:Expressed in brain, colon and several tumor-derived cell lines.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
