BD-PB4138-XRN1 (13A12) Mouse Monoclonal Antibody-现货抗体产品库武汉枢密脑科学技术有限公司

XRN1 (13A12) Mouse Monoclonal Antibody

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产品基本信息

产品货号

BD-PB4138

产品名称

XRN1 (13A12) Mouse Monoclonal Antibody

别名

5'-3' exoribonuclease 1, 3.1.13.-, Strand-exchange protein 1 homolog, XRN1, SEP1

类别

常规抗体

推荐应用

反应种属

Human, Mouse

Human Swissprot No.

Q8IZH2

特异性

This XRN1 antibody is generated from a mouse immunized with arecombinant protein between1455-1706 amino acids from human XRN1.

稀释度

WB~~1:2000

预测分子量

194kDa

同种型

IgG1,k

背景介绍

Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS).

组织表达

Expressed in heart, brain, pancreas, spleen, testis, osteogenic sarcoma (OGS) biopsy and primary cell lines

细胞定位

Cytoplasm. Note=Discrete foci at the inner surface of the cell membrane

期货

现货

All lanes : Anti-XRN1 Antibody at 1:2000 dilution Lane 1: K562 whole cell lysate Lane 2: MCF-7 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 194 kDa Blocking/Dilution buffer: 5% NFDM/TBST.