产品名称
CREB3L4 (10A18) Mouse Monoclonal Antibody (M01)
别名
Cyclic AMP-responsive element-binding protein 3-like protein 4, cAMP-responsive element-binding protein 3-like protein 4, Androgen-induced basic leucine zipper protein, AIbZIP, Attaching to CRE-like 1, ATCE1, Cyclic AMP-responsive element-binding protein 4, CREB-4, cAMP-responsive element-binding protein 4, Transcript induced in spermiogenesis protein 40, Tisp40, hJAL, Processed cyclic AMP-responsive element-binding protein 3-like protein 4, CREB3L4, AIBZIP, CREB4, JAL
Human Swissprot No.
Q8TEY5
特异性
This CREB3L4 antibody is generated from mice immunized with a recombinant between 1-300 amino acids from the region of human CREB3L4.
背景介绍
Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements (By similarity).
组织表达
According to PubMed:11830526, exclusively expressed in the prostate. Expressed in breast and prostate cancer cell lines Expressed in prostatic luminal epithelial cells (at protein level) Expression is significantly more abundant in prostate cancer than in benign prostatic tissue (prostatic hyperplasia). According to PubMed:12111373, also expressed in brain, pancreas and skeletal muscle, and at lower levels in small intestine, testis, leukocyte and thymus
细胞定位
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single- pass type II membrane protein. Note=May also be located in Golgi apparatus