BD-PB4058

VRK1 (3P16) Mouse Monoclonal Antibody (Center)(Ascites)

Serine/threonine-protein kinase VRK1, Vaccinia-related kinase 1, VRK1

常规抗体

WB

Human

NP_003375.1

Q99986

Purified His-tagged VRK1 protein was used to produced this monoclonal antibody.

WB~~1:5000

45kDa

IgG1

Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm.

Widely expressed. Highly expressed in fetal liver, testis and thymus.

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=Dispersed throughout the cell but not located on mitotic spindle or chromatids during mitosis

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