BD-PB4057-SUMO2 (18V6) Mouse Monoclonal Antibody (C-term)-现货抗体产品库武汉枢密脑科学技术有限公司

SUMO2 (18V6) Mouse Monoclonal Antibody (C-term)

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产品基本信息

产品货号

BD-PB4057

产品名称

SUMO2 (18V6) Mouse Monoclonal Antibody (C-term)

别名

Small ubiquitin-related modifier 2, SUMO-2, HSMT3, SMT3 homolog 2 {ECO:0000312|HGNC:HGNC:11125}, SUMO-3, Sentrin-2, Ubiquitin-like protein SMT3B, Smt3B, SUMO2 (HGNC:11125)

类别

常规抗体

推荐应用

反应种属

Human, Rat

Human Gene ID

NP_001005849.1;NP_008868.3

Human Swissprot No.

P61956

特异性

Purified His-tagged SUMO2 protein was used to produced this monoclonal antibody.

稀释度

IF~~1:25;WB~~1:1000

预测分子量

11kDa

同种型

IgG2b

背景介绍

Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.

组织表达

Broadly expressed..

细胞定位

Nucleus. Nucleus, PML body.

期货

现货

Fluorescent image of Hela cells stained with SUMO2 Antibody (C-term). BD-PB4057 was diluted at 1:25 dilution. An Alexa Fluor® 488-conjugated goat anti-mouse lgG at 1:400 dilution was used as the secondary antibody (green). Cytoplasmic actin was counterstained with Alexa Fluor® 555 conjugated with Phalloidin (red).

SUMO2 Antibody (C-term)western blot analysis in CEM,293,rat C6 cell line lysates (35μg/lane).This demonstrates the SUMO2 antibody detected the SUMO2 protein (arrow).