产品名称
UPF3B Rabbit Polyclonal Antibody (Center)
别名
Regulator of nonsense transcripts 3B, Nonsense mRNA reducing factor 3B, Up-frameshift suppressor 3 homolog B, hUpf3B, Up-frameshift suppressor 3 homolog on chromosome X, hUpf3p-X, UPF3B, RENT3B, UPF3X
Human Gene ID
NP_075386.1;NP_542199.1
Human Swissprot No.
Q9BZI7
特异性
This UPF3B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 320-349 amino acids from the Central region of human UPF3B.
背景介绍
UPF3B is a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. This protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions.
组织表达
Expressed in testis, uterus, prostate, heart, muscle, brain, spinal cord and placenta.
细胞定位
Nucleus. Cytoplasm. Note=Shuttling between the nucleus and the cytoplasm
